TECHNOLOGIST IN HEMATOLOGY

Heme biosynthesis occurs in the mitochondria and cytoplasm of bone marrow erythroid precursors

The root cause of megaloblastic anemia is impaired DNA synthesis. When either folate or vitamin B₁₂ is deficient, thymidine nucleotide production for DNA synthesis is impaired. Megaloblastic anemia is one example of a macrocytic anemia.

Intrinsic hemolytic anemias comprise a large group of disorders in which defects in the red blood cells (RBCs) result in premature hemolysis and anemia. Intrinsic disorders can be divided into abnormalities of the RBC membrane, metabolic enzymes, or hemoglobin. Most of these defects are hereditary.